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Patent Searching and Data


Title:
CLASS II PROTEIN OF EXOSPORIUM OF NEISSERIA MENINGITIDIS WITH IMMUNE CARRIER AND REINFORCEMENT PROPERTY
Document Type and Number:
Japanese Patent JPH0656690
Kind Code:
A
Abstract:
PURPOSE: To enhance immune response to an antigen by administering outer membrane protein of Gram-negative bacteria, which has an immunological enhancement effect, cytokinin induction activity, mitogenic characteristics and immunological carrier characteristics. CONSTITUTION: Immune response to an antigen can be enhanced by administering pure protein purified from the outer membrane of Gram-negative bacteria or preferably, class II protein (major immunological enhancement protein (MIEP)) of the outer membrane of Neisseria meningitidis (N. meningitidis) serum group B. A preferred production process of the MIEP comprises: culturing N. meningitidis to obtain a cultured material; forming an protein complex of the outer membrane of N. meningitidis from the cultured material by using a well-known method; and isolating and purifying the MIEP from the protein complex by using SDS(sodium dodecyl sulfate)- polyacrylamide gel electrophoresis. Also, another preferred production process comprises: incorporating DNA encoding the MIEP derived from N. meningitidis into vectors; and producing the MIEP in host cells transformed by the vectors.

Inventors:
AREN AI ORIFU
MAAGARETSUTO EE RIU
AASAA FURIIDOMAN
JIYOSEFU WAI TAI
JIYON JIEE DONERII
Application Number:
JP26996491A
Publication Date:
March 01, 1994
Filing Date:
July 19, 1991
Export Citation:
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Assignee:
MERCK & CO INC
International Classes:
A61K38/00; A61K39/00; A61K39/02; A61K39/095; A61K39/12; A61K39/35; A61K39/385; A61K39/39; A61P37/04; A61P43/00; C07K14/005; C07K14/195; C07K14/41; C07K14/705; C07K19/00; C12N1/20; C12N15/09; C12N15/31; C12P21/00; C12R1/19; C12R1/36; C12R1/865; A61K; C07K; (IPC1-7): A61K37/02; A61K39/00; A61K39/02; A61K39/12; A61K39/35; A61K39/385
Attorney, Agent or Firm:
Masao Okabe (6 others)