Title:
潜在的な抗マイコバクテリア剤としての１０−α／β−Ｄ−アラビノフラノシル−ウンデセンの合成
Document Type and Number:
Japanese Patent JP2014526502
Kind Code:
A
Abstract:
Disclosed herein is 10-α/β-D-Arabinofuranosylundecenes of general Formula (II) or pharmaceutically acceptable N salts thereof as anti-mycobacterial agents in vitro; (II) wherein R, R1 and R″ are as defined herein in the specification. The present invention also discloses a simple stereoselective synthesis 10-α/β-D-Arabinofuranosylundecenes of Formula (II) to target enzymes involved in the biosynthesis of cell wall of Mycobacterium and thus useful as inhibitors in the Mycobacterium tuberculosis drug development.
Inventors:
ラーマナ ヴェーンカタ Choi Puri
Deman Sal Cal
ラーフル シヴァジ Patil
Samppa Sal Cal
Deman Sal Cal
ラーフル シヴァジ Patil
Samppa Sal Cal
Application Number:
JP2014530384A
Publication Date:
October 06, 2014
Filing Date:
September 14, 2012
Export Citation:
Assignee:
Council オブ Scientific And Industrial Research
International Classes:
C07D307/20; A61K31/341; A61K31/7028; A61K31/7048; A61P31/06; C07H9/04; C07H17/04
Foreign References:
| US20080015344A1 | 2008-01-17 | |||
| US20080015344A1 | 2008-01-17 |
Other References:
JPN6015049957; ＣＡＲＢＯＨＹＤＲＡＴＥ ＲＥＳＥＡＲＣＨ ｖｏｌ． ３３８， ｎｏ． ７, 2003, ｐａｇｅｓ ５８１-５８８
JPN6015049958; ＴＨＥ ＪＯＵＲＮＡＬ ＯＦ ＯＲＧＡＮＩＣ ＣＨＥＭＩＳＴＲＹ ｖｏｌ． ６８， ｎｏ． ２, 2003, ｐａｇｅｓ ８１１５-８１１９
JPN6015049959; ＢＩＯＯＲＧＡＮＩＣ ＆ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ ｖｏｌ． １２， ｎｏ． ２１, 2004, ｐａｇｅｓ ５４９５-５５０３
JPN6015049960; ＣＡＲＢＯＨＹＤＲＡＴＥ ＲＥＳＥＡＲＣＨ ｖｏｌ． ３１７， ｎｏ． １-４, 1999, ｐａｇｅｓ １６４-１７９
JPN6015049957; ＣＡＲＢＯＨＹＤＲＡＴＥ ＲＥＳＥＡＲＣＨ ｖｏｌ． ３３８， ｎｏ． ７, 2003, ｐａｇｅｓ ５８１-５８８
JPN6015049958; ＴＨＥ ＪＯＵＲＮＡＬ ＯＦ ＯＲＧＡＮＩＣ ＣＨＥＭＩＳＴＲＹ ｖｏｌ． ６８， ｎｏ． ２, 2003, ｐａｇｅｓ ８１１５-８１１９
JPN6015049959; ＢＩＯＯＲＧＡＮＩＣ ＆ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ ｖｏｌ． １２， ｎｏ． ２１, 2004, ｐａｇｅｓ ５４９５-５５０３
JPN6015049960; ＣＡＲＢＯＨＹＤＲＡＴＥ ＲＥＳＥＡＲＣＨ ｖｏｌ． ３１７， ｎｏ． １-４, 1999, ｐａｇｅｓ １６４-１７９
JPN6015049958; ＴＨＥ ＪＯＵＲＮＡＬ ＯＦ ＯＲＧＡＮＩＣ ＣＨＥＭＩＳＴＲＹ ｖｏｌ． ６８， ｎｏ． ２, 2003, ｐａｇｅｓ ８１１５-８１１９
JPN6015049959; ＢＩＯＯＲＧＡＮＩＣ ＆ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ ｖｏｌ． １２， ｎｏ． ２１, 2004, ｐａｇｅｓ ５４９５-５５０３
JPN6015049960; ＣＡＲＢＯＨＹＤＲＡＴＥ ＲＥＳＥＡＲＣＨ ｖｏｌ． ３１７， ｎｏ． １-４, 1999, ｐａｇｅｓ １６４-１７９
JPN6015049957; ＣＡＲＢＯＨＹＤＲＡＴＥ ＲＥＳＥＡＲＣＨ ｖｏｌ． ３３８， ｎｏ． ７, 2003, ｐａｇｅｓ ５８１-５８８
JPN6015049958; ＴＨＥ ＪＯＵＲＮＡＬ ＯＦ ＯＲＧＡＮＩＣ ＣＨＥＭＩＳＴＲＹ ｖｏｌ． ６８， ｎｏ． ２, 2003, ｐａｇｅｓ ８１１５-８１１９
JPN6015049959; ＢＩＯＯＲＧＡＮＩＣ ＆ ＭＥＤＩＣＩＮＡＬ ＣＨＥＭＩＳＴＲＹ ｖｏｌ． １２， ｎｏ． ２１, 2004, ｐａｇｅｓ ５４９５-５５０３
JPN6015049960; ＣＡＲＢＯＨＹＤＲＡＴＥ ＲＥＳＥＡＲＣＨ ｖｏｌ． ３１７， ｎｏ． １-４, 1999, ｐａｇｅｓ １６４-１７９
Attorney, Agent or Firm:
Ueda Kunio
Takaharu Fujita
Miki Kawakami
Takaharu Fujita
Miki Kawakami