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Title:
COMPOSITION AND METHOD FOR DIAGNOSIS AND THERAPY OF BCL2-ASSOCIATED CANCER
Document Type and Number:
Japanese Patent JP2013166766
Kind Code:
A
Abstract:

To provide a method and a composition for the treatment of cancers associated with overexpression of a BCL2 gene and/or gene product in a subject, and a method and a composition for the improvement of anti-cancer therapy, such as chemotherapy and radiation therapy, and to provide a method for determining the efficacy of a cancer therapy in a subject and a method for inducing apoptosis of a cell.

A method for enhancing the efficacy of anti-cancer treatment in a subject having BCL2-associated cancer includes: (a) administration of at least one anti-cancer treatment to a subject; and (b) administration of at least one miR gene product to the subject, wherein at least one miR gene product contains a nucleotide sequence which is complementary to a nucleotide sequence in a BCL2 gene transcript; and thereby the efficacy of anti-cancer treatment can be enhanced.


Inventors:
CROCE CARLO M
CALIN GEORGE A
Application Number:
JP2013000081761
Publication Date:
August 29, 2013
Filing Date:
April 10, 2013
Export Citation:
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Assignee:
OHIO STATE UNIV RES FOUNDATION
International Classes:
A61K45/00; A61K31/4745; A61K31/475; A61K31/513; A61K31/519; A61K31/573; A61K31/704; A61K31/7048; A61K31/706; A61K31/7105; A61K33/24; A61K48/00; A61P35/00; A61P35/02; A61P43/00; C12N15/113; C12N15/09
Foreign References:
WO2004043387A22004-05-27
Other References:
JPN6012004354; CHEN,C. et al: Seminars in immunology Vol.17, No.2, 200504, p.155-65
JPN6013034748; JOHNSON,R.E.: International journal of radiation oncology, biology, physics Vol.5, No.2, 1979, p.159-64
JPN6013034751; FAGUET,G.B.: Journal of clinical oncology Vol.12, No.9, 1994, p.1974-90
JPN6013034748; JOHNSON,R.E.: International journal of radiation oncology, biology, physics Vol.5, No.2, 1979, p.159-64
JPN6013034751; FAGUET,G.B.: Journal of clinical oncology Vol.12, No.9, 1994, p.1974-90
Attorney, Agent or Firm:
小野 新次郎
小林 泰
富田 博行
星野 修
廣瀬 しのぶ