Title:
COMPOSITION AND METHOD FOR ENHANCING PHARMACOLOGICAL ACTIVITY AFTER ORAL AND PARENTERAL ADMINISTRATION OF COMPOSITION COMPRISING POLYPEPTIDE-DRUG SUBSTANCE AND OTHER POORLY ABSORBED ACTIVE INGREDIENT
Document Type and Number:
Japanese Patent JP2009235082
Kind Code:
A
Abstract:
To provide new pharmaceutical agents and compositions as well as new methods for enhancing the absorption of polypeptide drug substances that normally display little if any absorbability when administered orally, and also to provide new compositions and methods for significantly enhancing the bioavailability and pharmacological efficacy of polypeptide drug substances whether administered orally or parenterally.
The method includes generating a prodrug by chemically linking a therapeutic polypeptide of general formula: aan (wherein aa is an amino acid; and n is an integer of 2 to 40) to an alkyl or aryl carrier moiety to form a prodrug, and administering the prodrug to mammals excluding humans exhibiting physiological abnormality.
Inventors:
ZIMMER ROBERT H
Application Number:
JP2009137059A
Publication Date:
October 15, 2009
Filing Date:
June 08, 2009
Export Citation:
Assignee:
ZIMMER ROBERT H
International Classes:
A61K38/00; A61K38/22; A61K47/48; A61P25/04; A61P31/00; A61P31/12; A61P35/00; A61P43/00
Foreign References:
| WO1998053050A2 | 1998-11-26 | |||
| WO1998008868A1 | 1998-03-05 | |||
| WO1998053050A2 | 1998-11-26 | |||
| WO1998008868A1 | 1998-03-05 |
Other References:
JPN6011046093; Ｉｎｔ． Ｊ． Ｐｈａｒｍ． Ｖｏｌ．７６, 1991, １１３-１２２
JPN6011046093; Ｉｎｔ． Ｊ． Ｐｈａｒｍ． Ｖｏｌ．７６, 1991, １１３-１２２
JPN6011046093; Ｉｎｔ． Ｊ． Ｐｈａｒｍ． Ｖｏｌ．７６, 1991, １１３-１２２
Attorney, Agent or Firm:
Akira Okawa