CONDENSED BENZENOXYACETIC ACID DERIVATIVE, ITS PRODUCTION AND PHARMACEUTICAL AGENT CONTAINING THE DERIVATIVE AS ACTIVE COMPONENT

Japanese Patent JP3117800

B2

PURPOSE: To provide a new compound having PGI2 receptor agonistic action and useful for the prevention and treatment of thrombosis, arteriosclerosis, ischemic cardiopathy, gastric ulcer, hypertension, etc.
CONSTITUTION: The compound of formula I [group of formula II is formula III ((e) is 3-5; (p) is 0-4), etc.; A is group of formula IV (R2 is H, 1-6C alkyl or phenyl), etc.; R1 is H or 1-4C alkyl; R3 is 1-15C alkyl, benzene ring, 4-7C cycloalkane, etc.], e.g. [2-[2-[1-phenyl-1-(4-pyridyl)methyloxyimino]-propyl]-1,2,3,4- tetrahydronaphthalen-5-yloxy]acetic acid. The compound of formula I can be produced e.g. by hydrolyzing a compound of formula V (R1a is 1-4C alkyl).

JPH03502456	[Title of the Invention] 3, 18 ‐Dihydroxy‐ 9, 13 ‐Epoxy shrub out derivatives, those preparing methods, and an arrest-of-hemorrhage medicine tablet based on them
JP2897832	[Title of Invention] A photoprotective composition containing a chelating agent

Nobuyuki Hamanaka
Kanji Takahashi
Hidemon Tokumoto

JP20714592A

December 18, 2000

July 10, 1992

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Ono Pharmaceutical Co., Ltd.

A61K31/19; A61K31/215; A61K31/40; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4418; A61K31/55; A61P1/04; A61P7/02; A61P9/08; A61P9/10; A61P9/12; C07C51/09; C07C59/72; C07C67/31; C07C69/712; C07C239/20; C07C249/08; C07C249/12; C07C251/40; C07C251/42; C07C251/48; C07C251/52; C07C251/54; C07D207/333; C07D213/30; C07D223/04; (IPC1-7): C07C59/72; A61K31/19; A61K31/215; A61K31/40; A61K31/44; A61K31/55; A61P1/04; A61P7/02; A61P9/10; A61P9/12; C07C51/09; C07C67/31; C07C69/712; C07C239/20; C07C249/08; C07C249/12; C07C251/40; C07C251/42; C07C251/48; C07C251/52; C07C251/54; C07D207/333; C07D213/30; C07D223/04

JP4334358A
JP5178832A
JP687811A

Landlord Kunihisa

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