Title:
溶媒を使用しないクロスカップリング反応及びその反応を用いる製造方法
Document Type and Number:
Japanese Patent JP7023019
Kind Code:
B2
Abstract:
Disclosed is a cross-coupling reaction method which forms a chemical bond selected from C-N, C-B, C-C, C-O and C-S bonds, the method comprising:preparing an aromatic compound (1) having a leaving group;preparing a compound (2) capable of undergoing a cross-coupling reaction selected from an aromatic amino compound (2-1), a diboronic acid ester or the like (2-2), an aromatic boronic acid or the like (2-3), an aromatic compound (2-4) having a hydroxyl group and an aromatic compound (2-5) having a thiol group; andperforming a cross-coupling reaction of the compound (1) with the compound (2) in the presence of a palladium catalyst, a base and a compound (4) having a carbon-carbon double bond or a carbon-carbon triple bond, in the absence of a solvent.
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Inventors:
Hajime Ito
Kubota Koji
Kubota Koji
Application Number:
JP2020553437A
Publication Date:
February 21, 2022
Filing Date:
October 23, 2019
Export Citation:
Assignee:
National University Corporation Hokkaido University
International Classes:
C07C209/10; B01J31/04; C07B37/04; C07B41/04; C07B43/04; C07B47/00; C07C15/14; C07C23/08; C07C43/205; C07C49/782; C07C69/76; C07C211/48; C07C211/54; C07C211/58; C07C211/60; C07C211/61; C07D209/88; C07D333/08; C07D333/36; C07D487/22; C07F5/02
Other References:
Journal of Organic Chemistry,81(20),2016年,p.10049-10055
Organic Process Research & Development,2009年,13(1),p.44-48
Tetrahedron Letters,2018年,59(23),p.2277-2280
Comprehensive Organic Synthesis (2nd Edition) ,2014年, Volume 9,p.287-314
Pure and Applied Chemistry,83(7),2011年,p.1343-1349
Organic Process Research & Development,2009年,13(1),p.44-48
Tetrahedron Letters,2018年,59(23),p.2277-2280
Comprehensive Organic Synthesis (2nd Edition) ,2014年, Volume 9,p.287-314
Pure and Applied Chemistry,83(7),2011年,p.1343-1349
Attorney, Agent or Firm:
Yamato Kento
Junichi
Fukusei
Junichi
Fukusei