CRYSTALLIZABLE MONOHYDRATE OF N-(1H-TETRAZOL-5-YL)-1-PHEOXY-4H-QUINOIZIN-4-ONE-3-CARBOXAMIDE SODIUM SALT AND PRODUCTION THEREOF

Title:

CRYSTALLIZABLE MONOHYDRATE OF N-(1H-TETRAZOL-5-YL)-1-PHEOXY-4H-QUINOIZIN-4-ONE-3-CARBOXAMIDE SODIUM SALT AND PRODUCTION THEREOF

Document Type and Number:

Japanese Patent JPH01104073

Kind Code:

A

Abstract:

NEW MATERIAL:Crystallizable monohydrate of N-(1H-tetrazol-5-yl)-phenoxy-4H- quinolizin-4-one-carboxamide sodium salt.

USE: An antiallergic drug and antitumor agent having excellent handleability because of extremely excellent water-vapor resistance and stability.

PREPARATION: N-( 1H-tetrazol-5-yl )-1-phenoxy-4H-quinolizin-4-one-3-carbax amide.sodium salt (or crystallizable tetrahydrate thereof) shown by the formula is crystallized (or subjected to crystal transition) at 40W80°C at ≥30% relative humidity or from a water-isopropyl alcohol mixed solvent to give a crystalliza ble monohydrate of the compound shown by the formula. The crystallizable tetrahydrate is obtained by crystallizing the compound shown by the formula from a water-ethanol mixed solvent.

Inventors:

KITAMURA SATOSHI
OKAMOTO YOSHIHIKO
TADA TOSHIHARU
MOMONAGA SHINJI

Application Number:

JP18925088A

Publication Date:

April 21, 1989

Filing Date:

July 27, 1988

Export Citation:

Click for automatic bibliography generation Help

Assignee:

FUJISAWA PHARMACEUTICAL CO

International Classes:

C07D455/02; A61K31/435; A61P1/04; A61P37/08; (IPC1-7): C07D455/02

Attorney, Agent or Firm:

Kuichi Ueki (1 person outside)

Previous Patent: JPH01104072

Next Patent: PIPERAZINYL DERIVATIVE OF PURINE AND ISOSTER THEREOF AS HYPOGLYCEMIC AGENT