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Title:
【発明の名称】組み換えG-CSF
Document Type and Number:
Japanese Patent JP2766621
Kind Code:
B2
Abstract:
For the enzymatic cleavage of fused proteins and obtaining of desired portions of these fused proteins, (1) genetic engineering means are used to modify a junction region in which two portions of the fused protein are connected together so that in this junction region at least one IgA protease recognition site with the amino-acid sequence Y-Pro.<&darr& >.X-Pro is produced, where X can be any amino acid and Y can be any one or more amino acids, (2) the fused protein resulting from step (1) is cleaved by IgA protease at the position identified by .<&darr& >. in the recognition site and (3) after the cleavage one or more desired portions of the fused protein are obtained.

Inventors:
MEIYAA TOOMASU EFU
HOORUNAA YOHANSU
SHUMASHEERU GUUNTAA
DONII KARORA
Application Number:
JP12095A
Publication Date:
June 18, 1998
Filing Date:
January 04, 1995
Export Citation:
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Assignee:
MATSUKUSU PURANKU G TSUA FUERUDERUNKU DERU UITSUSENSHAFUTEN EE FUAU
International Classes:
A61K38/18; A61P37/04; C07K14/00; C07K14/28; C07K14/52; C07K14/53; C07K14/535; C07K14/54; C07K14/55; A61K38/00; C07K14/705; C07K19/00; C12N1/19; C12N1/21; C12N9/12; C12N9/52; C12N15/09; C12N15/57; C12N15/62; C12N15/70; C12P21/02; C12P21/06; C12R1/19; C12R1/42; (IPC1-7): C07K14/535; A61K38/00; C12N15/09
Domestic Patent References:
JP3500483A
Attorney, Agent or Firm:
Yusuke Hiraki (2 outside)