PURPOSE: To obtain the subject novel inhibitor which inhibits the angiotensinogen-cleaving action of a natural proteolytic enzyme, renin, and is useful in treating or preventing renin-associated hypertension, hyperaldosteronism, glaucoma, or the like.
CONSTITUTION: There is provided an inhibitor of formula I {wherein A is H, or a heterocyclic group such as quinuclidinyl, piperidinyl or oxazolyl; B is O-CH[(CH2)rR3]CO-O, N(A1)CH{(CH2)rR3} CH(OH)CH2 (wherein (r) is 0-2; A1 is H or a 1-4C alkyl; R3 is H, a 1-4C alkyl, or the like), or the like; W is O, N(R23) (wherein R23 is H or a 1-4C alkyl); Y is O-CO, CH2-CO, or the like; D is N(R25)CO (wherein R25 is H or a 1-4C alkyl), or the like; R1 and R16 are each H, a 1-4C alkyl, or the like; R15 is a 1-4C alkyl, phenyl, or the like; R24 is H or a 1-4C alkyl; (s) is 0-1; (r) is 0-2; (t) is 1-4; and Z is NH-OH or the like}, for example, a compound of formula II.
AASAA EE PACHIETSUTO
UIRIAMU JIEE GURIINRII
UIRIAMU ETSUCHI PAASONZU
TOOMASU EE HARUGUREN
AN II UEBAA
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