Title:
CYCLOPROPYL DERIVATIVE LIPOXYGENASE INHIBITOR
Document Type and Number:
Japanese Patent JPH06306038
Kind Code:
A
Abstract:
PURPOSE: To obtain a cyclopropyl derivative which inhibits 5-and/or 12- lipoxygenase useful for the treatment of inflammatory diseases.
CONSTITUTION: The compound of formula I {X is absent or 1-4C alkylene; Y is absent or 1-4C alkylene; R1 is H, carbocyclic aryl, heterocyclic aryl, carbocyclic aryloxy or heterocyclic aryloxy; R2 is formula II or formula III [Z is H, metabolically cleavable group or pharmaceutically acceptable cation; R3 is H, 1-6C alkyl, 4-12C cycloalkyl, mono- or di- 1-6C alkylamino, (cycloalkyl) amino, 2-hydroxyethylamino, N-(thio)morpholino, formula IV (n is 3 to 8) or formula V (R9 is H or 1-6C alkyl); R4 is H, 1-6C alkyl or 3-8C cycloalkyl]; R5 is H or 1-4C alkyl; R6 and R7 are each R5 or halogen; R8 is R5}, e.g. N-(1- cis-(2-phenylcyclopropyl)methyl)-N-hydroxyurea, is obtained.
Inventors:
DEII DABURIYU BURUTSUKUSU
KAREN II RODORITSUKESU
BURUUSU DABURIYU HOOROMU
HOOMOZU MAJIYASUNI
Application Number:
JP41931390A
Publication Date:
November 01, 1994
Filing Date:
December 28, 1990
International Classes:
A61K31/17; A61K31/335; A61K31/357; A61K31/38; A61K31/381; A61K31/40; A61K31/403; A61K31/404; A61K31/425; A61K31/426; A61K31/44; A61K31/4402; A61K31/4406; A61K31/4409; A61K31/4412; A61K31/4418; A61K31/443; A61K31/445; A61K31/47; A61K31/495; A61K31/535; A61K31/5375; A61K31/54; A61P29/00; A61P43/00; C07C239/08; C07C259/06; C07C259/08; C07C275/64; C07D207/335; C07D209/14; C07D213/30; A61K31/16; C07D213/40; C07D213/42; C07D213/61; C07D213/643; C07D213/65; C07D213/68; C07D215/12; C07D239/26; C07D277/28; C07D277/34; C07D277/64; C07D295/20; C07D307/52; C07D307/56; C07D307/58; C07D307/81; C07D307/83; C07D317/58; C07D319/18; C07D333/16; C07D333/20; C07D333/28; C07D333/32; C07D333/56; C07D333/58; C07D333/64; C07D405/04; C07D409/04; C07D207/32; C07D213/64; (IPC1-7): C07C259/06; A61K31/16; A61K31/17; A61K31/335; A61K31/38; A61K31/40; A61K31/425; A61K31/44; A61K31/445; A61K31/47; A61K31/495; A61K31/535; A61K31/54; C07C239/08; C07C259/08; C07C275/64; C07D209/14; C07D213/42; C07D215/12; C07D239/26; C07D277/28; C07D295/20; C07D307/52; C07D307/58; C07D307/81; C07D307/83; C07D317/58; C07D319/18; C07D333/20; C07D333/32; C07D333/58; C07D333/64; C07D405/04
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)
