Title:
サイトカイン受容体
Document Type and Number:
Japanese Patent JP2005517227
Kind Code:
A
Abstract:
A crystalline composition comprising a crystal of the IL-6 receptor I chain is provided. Also provided are methods of using the crystal and related structural information to screen for and design compounds that interact with IL-6R, or variants thereof. Also provided arc methods of modulating an IL-6 receptor comprising contacting the IL-6 receptor with a compound identified by the screening method of the invention.
Inventors:
Barges Joseph Notchumatry
Simpson richard jay
Moritz Robert Lorenz
Lou Meizen
Ji Hong
Branson Kim Matthew
Smith Brian John
Simpson richard jay
Moritz Robert Lorenz
Lou Meizen
Ji Hong
Branson Kim Matthew
Smith Brian John
Application Number:
JP2003528862A
Publication Date:
June 09, 2005
Filing Date:
September 16, 2002
Export Citation:
Assignee:
Commonwealth Scientific and Industrial Research Organization
Ludwig Institute for Cancer Research
Walter and Eliza Hall Institute of Medical Research
Ludwig Institute for Cancer Research
Walter and Eliza Hall Institute of Medical Research
International Classes:
G01N33/15; A61K31/00; A61K31/122; A61K31/136; A61K31/166; A61K31/167; A61K31/185; A61K31/19; A61K31/325; A61K31/343; A61K31/352; A61K31/381; A61K31/4035; A61K31/407; A61K31/428; A61K31/435; A61K31/437; A61K31/4375; A61K31/4709; A61K31/472; A61K31/4741; A61K31/4745; A61K31/519; A61K31/522; A61K31/704; A61K45/00; A61P13/12; A61P17/00; A61P17/06; A61P19/02; A61P19/10; A61P29/00; A61P31/04; A61P31/18; A61P35/00; A61P37/00; A61P43/00; C07D203/18; C07D209/48; C07D217/06; C07D219/04; C07D219/12; C07D277/60; C07D307/77; C07D311/30; C07D311/62; C07D333/48; C07D401/12; C07D473/34; C07D487/04; C07D487/06; C07D491/18; C07D498/04; C07D515/22; C07D519/00; C07H15/20; C07K14/705; C07K14/715; G06F19/00; G16B15/30; (IPC1-7): G06F19/00; A61K31/122; A61K31/136; A61K31/166; A61K31/167; A61K31/185; A61K31/19; A61K31/343; A61K31/352; A61K31/381; A61K31/4035; A61K31/407; A61K31/428; A61K31/435; A61K31/437; A61K31/4375; A61K31/4709; A61K31/472; A61K31/4741; A61K31/4745; A61K31/519; A61K31/522; A61K31/704; A61K45/00; A61P13/12; A61P17/06; A61P19/02; A61P19/10; A61P29/00; A61P31/04; A61P31/18; A61P35/00; A61P43/00; C07D203/18; C07D209/48; C07D217/06; C07D219/04; C07D219/12; C07D277/60; C07D307/77; C07D311/30; C07D311/62; C07D333/48; C07D401/12; C07D473/34; C07D487/04; C07D487/06; C07D491/18; C07D498/04; C07D515/22; C07D519/00; C07H15/20; C07K14/705; G01N33/15
Attorney, Agent or Firm:
Hatsushi Shimizu
Kazunori Hashimoto
Koichi Niimi
Kazunori Hashimoto
Koichi Niimi