To obtain a desmosome decomposition accelerator capable of keeping healthy skin by including hydroxycarboxylic acids.
This medicine contains 0.01-20wt.% of a hydroxycarboxylic acid expressed by the formula R(CHOH)nCOOH {R is H, a 1-21C alkyl or aldehyde; (n) is 1-8; when (n)≥2, one of hydroxymethylene may be replaced with carbonyl} or their glycolide, lactide or lactone as an active component. The decomposition accelerator of desmosome can impart an aqueous environment attaining desquamation of a horny layer to the skin and increase an activity itself decomposition a protein existing in desmosome, at least desmograin, and further desmocholine. By the process, a preparation for external use for skin especially useful for accelerating peel-off of the horny layer can be provided.
MASUDA YOSHIKO
KOYAMA JUNICHI
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