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Title:
DIAGNOSIS AND MEDICAL TREATMENT OF CROHN'S DISEASE USING ERGOTHIONEINE
Document Type and Number:
Japanese Patent JP2009192383
Kind Code:
A
Abstract:

To provide a novel means for diagnosing and treating a Crohn's disease by elucidating the participation of OCTN1 and ergothioneine in the morbid state or sideration of the Crohn's disease.

The level of ergothioneine in a sample isolated from a subject is used as the index to diagnose the Crohn's disease. The affection risk of the Crohn's disease is diagnosed on the basis of the detection of a diplotype 1 in the sample isolated from the subject. A preventing or treating composition contains ergothioneine or its simulant as an effective component.


Inventors:
TSUJI AKIRA
KATO MASAO
KUBO YOSHIYUKI
KANEKO SHUICHI
KAGAYA NAOFUMI
SOGA TOMOYOSHI
Application Number:
JP2008000033588
Publication Date:
August 27, 2009
Filing Date:
February 14, 2008
Export Citation:
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Assignee:
UNIV KANAZAWA
International Classes:
G01N33/68; A61K31/4164; A61P1/04; C12Q1/68; G01N33/53; C07D233/84; C12N15/09
Foreign References:
Other References:
JPN6013027481; Taubert D: 'Functional role of the 503F variant of the organic cation transporter OCTN1 in Crohn's disease.' Gut Vol.54/No.10, 200510, 1505-1506
Attorney, Agent or Firm:
平木 祐輔
石井 貞次
藤田 節
松任谷 優子