Title:
Dihydro Pteridinone II
Document Type and Number:
Japanese Patent JP6072308
Kind Code:
B2
Abstract:
The present invention relates to spiroheterocycl-dihydropyhmidines, their use as modulators of γ-secretase and to pharmaceutical compositions containing said compounds. In particular, the present invention relates to compounds which interfere with γ-secretase and/or its substrate and therefore modulate the formation of Αβ peptides.
Inventors:
Ikemeier Christian
Gerlach Kai
Heine Niclas
Weber alexander
Gloss Urrique
Gerlach Kai
Heine Niclas
Weber alexander
Gloss Urrique
Application Number:
JP2015558352A
Publication Date:
February 01, 2017
Filing Date:
February 21, 2013
Export Citation:
Assignee:
Boehringer Ingelheim International GmbH
International Classes:
C07D475/12; A61K31/527; A61K31/529; A61P9/00; A61P25/00; A61P25/28; A61P27/02; A61P27/04; A61P27/06; A61P43/00; C07D491/20
Domestic Patent References:
| JP2012516870A | ||||
| JP2012526078A | ||||
| JP2012515205A | ||||
| JP2008510771A | ||||
| JP2005501904A | ||||
| JP2006514667A |
Foreign References:
| WO2006091737A1 |
Other References:
SONG, B. et al.,Inhibition of Polo-like kinase 1 reduces beta-amyloid-induced neuronal cell death in Alzheimer's disease,Aging,2011年,3(9),pp. 846-851
Attorney, Agent or Firm:
Koichi Tsujii
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Akizawa
Sadao Kumakura
Atsushi Hakoda
Kenji Asai
Kazuo Yamazaki
Satsuki Ichikawa
Akizawa