PURPOSE: To provide the subject new diphenoxybenzene derivative exhibiting an excellent antitumor effect and to provide a new compound exhibiting an excellent antitumor effect and useful as an intermediate for production of the above-mentioned new diphenoxybenzene.
CONSTITUTION: A diphenoxybenzene derivative of formula I (R1 to R4 are each H, OH, an alkyl, an alkenyl, an aralkyl or an acyl; X1 to X4 are each H or a halogen), e.g. 2-(4-amino-2,6-dichlorophenyloxy)-1,4-dimethoxy-6-[-N-(3-hydroxy-4- methoxybenzyl)amino]benzene and a compound represented by formula II, e.g. 2,6-bis(4-amino-2,6-dichlorophenyloxy)-1,4-dimethoxybenzene. The compound of formula I can be obtained, e.g. by reacting a new compound of formula II with a compound of formula III (Y is an eliminable group; R5 is an alkyl or an aralkyl). The compound of formula II is readily obtained by reducing a compound of formula IV.
TAKAHASHI AKIRA
NUNOSAWA TETSUJI
ENDO TAKESHI
