Title:
GSNOの充足を起こすガス状薬剤による肺疾患の処置
Document Type and Number:
Japanese Patent JP4652664
Kind Code:
B2
Abstract:
Pulmonary disorders in which the GSNO pool or glutathione pool in the lung is depleted and where reactive oxygen species in lung are increased, are treated by delivering into the lung as a gas, agent causing repletion or increase of the GSNO pool or protection against toxicity and does so independently of reaction with oxygen. Agents include ethyl nitrite, NOCl, NOBr, NOF, NOCN, N2O3, HNO, and H2S. Optionally, N-acetylcysteine, ascorbate, H2S or HNO is administered in addition to other GSNO repleting agent to potentiate the effect of said agent.
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Inventors:
Jonathan S. Stamler
Application Number:
JP2002563828A
Publication Date:
March 16, 2011
Filing Date:
January 28, 2002
Export Citation:
Assignee:
DUKE UNIVERSITY
International Classes:
A61K9/72; A61K33/00; A61K31/16; A61K31/166; A61K31/197; A61K31/198; A61K31/21; A61K31/375; A61K33/04; A61K35/14; A61K35/18; A61K45/00; A61P7/06; A61P9/00; A61P9/10; A61P9/12; A61P11/00; A61P11/06; A61P21/00; A61P29/00; G01N31/00; G01N33/15; G01N33/50
Domestic Patent References:
| JP2003524630A | ||||
| JP2004511515A | ||||
| JP9512523A | ||||
| JP6504778A |
Attorney, Agent or Firm:
Aoyama Aoi
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima