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Title:
ENVIRONMENTALLY RESPONSE DRUG SUSTAINED RELEASE CONTROL MEMBRANE
Document Type and Number:
Japanese Patent JP2526401
Kind Code:
B2
Abstract:

PURPOSE: To obtain an environmentally response drug sustained release control membrane excellent in mechanical strength, showing high safety against a human body, having no problem even when scattered over a farm because of microbial biodegradability and gentle to a human being or the globe by using a water-insoluble silk fibroin membrane containing a crystalline substance.
CONSTITUTION: An environmentally resposive drug sustained release control membrane is obtained by forming a membrane from an aq. soln. of silk fibroin to crystallize the same, make a crystals contained in the membrane and make the membrane water-insoluble. When the drug sustained release control membrane is formed by crystallizing a silk fibroin membrane, at the degree of crystallization thereof the membrane can contain 10-60wt.% of moisture. This environmentally responsive drug sustained control membrane becomes drug sustained release properties or drug hardly sustained release properties by changing the pH of the aq. soln. brought into contact with the silk fibroin membrane. This function is developed because silk fibroin has a polar group such as an amino group because of protein and the degree of dissociation of the polar group is changed by pH.


Inventors:
箕浦 憲彦
Application Number:
JP1993000232458
Publication Date:
August 21, 1996
Filing Date:
August 25, 1993
Export Citation:
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Assignee:
工業技術院長
International Classes:
B01D69/02; B01D71/74; (IPC1-7): B01D71/74; B01D69/02
Domestic Patent References:
JP1254621A
JP1118544A
Attorney, Agent or Firm:
工業技術院物質工学工業技術研究所長