Title:
エリスロポエチン変異体
Document Type and Number:
Japanese Patent JP5231214
Kind Code:
B2
Abstract:
The present invention relates to novel endogenous variants of erythropoietin (EPO) and their use for treatment or prevention of a condition associated with tissue damage due to cell death (apoptosis, necrosis) and inflammtion, in particular for neuroprotection, e.g. treatment of acute (for example stroke) and chronic disease (for example ALS) of the nervous system.
More Like This:
Inventors:
Andreas, Meisel
Priller, joseph
Bonas, Christel
Durnagle, Ulrich
Priller, joseph
Bonas, Christel
Durnagle, Ulrich
Application Number:
JP2008510513A
Publication Date:
July 10, 2013
Filing Date:
May 15, 2006
Export Citation:
Assignee:
Charity Uniberg The Arts Medicin-Berlin
International Classes:
C12N15/09; A01K67/027; A61K31/7088; A61K38/00; A61K48/00; A61P9/04; A61P9/10; A61P11/00; A61P25/00; A61P25/04; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/28; A61P43/00; C07K14/505; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02
Domestic Patent References:
| JP3081294A | ||||
| JP60500558A |
Foreign References:
| WO2004043382A1 |
Other References:
WEN,D. et al.,Erythropoietin structure-function relationships: high degree of sequence homology among mammals.,Blood,1993年 9月 1日,Vol.82, No.5,pp.1507-16
BOISSEL,J.P. et al.,Erythropoietin structure-function relationships. Mutant proteins that test a model of tertiary structure.,J. Biol. Chem.,1993年 7月25日,Vol.268, No.21,pp.15983-93
CHERN,Y.J. et al.,Structural role of amino acids 99-110 in recombinant human erythropoietin.,Eur. J. Biochem.,1991年12月 5日,Vol.202, No,2,pp.225-9
WEN,D. et al.,Erythropoietin structure-function relationships. Identification of functionally important domains.,J. Biol. Chem.,1994年 9月 9日,Vol.269, No.36,pp.22839-46
GRODBERG,J. et al.,Alanine scanning mutagenesis of human erythropoietin identifies four amino acids which are critical for biological activity.,Eur. J. Biochem.,1993年12月 1日,Vol.218, No.2,pp.597-601
CAMPANA,W.M. e al.,Identification of a neurotrophic sequence in erythropoietin.,Int. J. Mol. Med.,1998年 1月,Vol.1, No.1,pp.235-41
LEIST,M. et al.,Derivatives of erythropoietin that are tissue protective but not erythropoietic.,Science,2004年 7月 9日,Vol.305, No.5681,pp.239-42
SASAKI,R.,Pleiotropic functions of erythropoietin.,Intern. Med.,2003年 2月,Vol.42, No.2,pp.142-9
BOISSEL,J.P. et al.,Erythropoietin structure-function relationships. Mutant proteins that test a model of tertiary structure.,J. Biol. Chem.,1993年 7月25日,Vol.268, No.21,pp.15983-93
CHERN,Y.J. et al.,Structural role of amino acids 99-110 in recombinant human erythropoietin.,Eur. J. Biochem.,1991年12月 5日,Vol.202, No,2,pp.225-9
WEN,D. et al.,Erythropoietin structure-function relationships. Identification of functionally important domains.,J. Biol. Chem.,1994年 9月 9日,Vol.269, No.36,pp.22839-46
GRODBERG,J. et al.,Alanine scanning mutagenesis of human erythropoietin identifies four amino acids which are critical for biological activity.,Eur. J. Biochem.,1993年12月 1日,Vol.218, No.2,pp.597-601
CAMPANA,W.M. e al.,Identification of a neurotrophic sequence in erythropoietin.,Int. J. Mol. Med.,1998年 1月,Vol.1, No.1,pp.235-41
LEIST,M. et al.,Derivatives of erythropoietin that are tissue protective but not erythropoietic.,Science,2004年 7月 9日,Vol.305, No.5681,pp.239-42
SASAKI,R.,Pleiotropic functions of erythropoietin.,Intern. Med.,2003年 2月,Vol.42, No.2,pp.142-9
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazumi Nakamura
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazumi Nakamura