ESTERIFICATION OF CARBOXYLIC ACID COMPOUND

Title:

ESTERIFICATION OF CARBOXYLIC ACID COMPOUND

Document Type and Number:

Japanese Patent JPH10158199

Kind Code:

A

Abstract:

To convert a carboxylic acid compound into an ester derivative without using an iodine compound while suppressing the formation of quaternarized by-product by treating a cfarboxylic acid compound with a specific compound in the presence of a phase-transfer catalyst.

(A) A mixture of a carboxylic acid compound and a base is treated with (B) a compound expressed by the formula, R1-X [R1 is a group forming an ester (COOR1) hydrolyzable in vivo; X is a halogen] in the presence of (C) a phase-transfer catalyst. Preferably, the component A is a β-lactam antibiotic substance, a penem antibiotic substance or a carbapenem antibiotic substance, the component C is benzyltriethylammonium halide, tetrabutylammonium halide or tetrabutylphosphonium halide and the component B is e.g. pivaloyloxymethyl chloride.

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Inventors:

NISHI TOSHIYUKI
ISHIDA YOHEI
OTSUKA MASAMI

Application Number:

JP26941597A

Publication Date:

June 16, 1998

Filing Date:

October 02, 1997

Export Citation:

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Assignee:

DAIICHI SEIYAKU CO

International Classes:

C07D519/00; A61K31/415; A61P31/04; B01J31/02; C07B41/12; C07B61/00; (IPC1-7): C07B41/12; B01J31/02; C07D519/00

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