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Title:
ETHANOBICYCLIC AMINE DERIVATIVE FOR CNS DISORDER
Document Type and Number:
Japanese Patent JPH04225969
Kind Code:
A
Abstract:

PURPOSE: To provide a new ethanobicyclic amine compound and its salt useful for alleviating or preventing nerve degeneration or as therapeutic agents for psychotic disorders, convulsions and cerebral ischemia.

CONSTITUTION: A compound of formula I [R1-R4, Y and Z are each hydrido, hydroxy, an alkyl, cycloalkyl, cycloalkylalkyl, etc.; R5-R10 are each hydrido, an alkyl, etc.; R7 and R8 together form oxo; R9 and R10 together form oxo; G is O, S, etc.; m is 1 or 2; p is 0-4; q and r are each 1-5; q+r is 3-10, etc.], e.g. 1-(2-benzobicyclo[2.2.2]octenyl)methylpiperidine. The compound is obtained, e.g. by converting an anthranilate of formula II into the diazonium salt, mixing the diazonium salt with a diene to convert into a compound of formula III, converting the product into an alcohol, oxidizing the alcohol to a ketone and mixing the ketone with an amine.


Inventors:
NANSHII EMU GUREI
BURAIAN KEI CHIENGU
Application Number:
JP9921291A
Publication Date:
August 14, 1992
Filing Date:
April 30, 1991
Export Citation:
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Assignee:
SEARLE & CO
International Classes:
A61K31/395; A61K31/40; A61K31/415; A61K31/42; A61K31/425; A61K31/445; A61K31/495; A61K31/535; A61K31/5375; A61K31/545; A61K31/55; A61P9/10; A61P25/08; A61P25/18; A61P25/28; C07D295/02; C07D295/033; C07D295/04; (IPC1-7): A61K31/395; A61K31/40; A61K31/415; A61K31/42; A61K31/425; A61K31/445; A61K31/495; A61K31/535; A61K31/545; A61K31/55; C07D295/02; C07D295/04