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Title:
FKBP TYPE PPIASE DERIVED FROM THERMOPHILIC ARCHAEBACTERIA BELONGING TO AEROPYRUM PERNIX AND GENE ENCODING THE SAME
Document Type and Number:
Japanese Patent JP2000083673
Kind Code:
A
Abstract:

To obtain the subject new gene, encoding a protein having a specific amino acid sequence and peptidyl prolyl cis-trans-isomerase activity and usable e.g. for production of the above enzyme useful e.g. for regeneration of denatured proteins and stabilization of protein reagents.

This new gene is such one as to encode a protein having an amino acid sequence described in the formula or a protein having an amino acid sequence wherein one or plural amino acid(s) is (are) deleted, substituted or added in the amino acid sequence described in the formula and consisting of a protein having peptidyl prolyl cis-trans isomerase activity and to have high heat resistance and to be useful e.g. for regeneration of denatured proteins, stabilization of protein reagents, production of recombinant proteins and elucidation of new immunosuppressive agents and physiologically active substances, and usable e.g. for production of the above enzymes. This gene is obtained by separating genomic DNA of aeropyrum pernix K1 strain, a thermophilic archaebacterium and conducting PCR of the DNA by using a primer consisting of a partial sequence.


Inventors:
IDENO AKIRA
MARUYAMA TADASHI
FURUYA MASAHIRO
Application Number:
JP1998000260517
Publication Date:
March 28, 2000
Filing Date:
September 14, 1998
Export Citation:
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Assignee:
MARINE BIOTECH INST CO LTD
SEKISUI CHEMICAL CO LTD
International Classes:
C12N15/09; C12N9/90; C12N15/00; C12R1/01; (IPC1-7): C12N15/09; C12N9/90
Attorney, Agent or Firm:
平木 祐輔 (外2名)