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Patent Searching and Data


Title:
GANGLIOSIDE GM3, INTERMEDIATE AND PRODUCTION THEREOF
Document Type and Number:
Japanese Patent JPH03112997
Kind Code:
A
Abstract:

NEW MATERIAL:A compound shown by formula I (R1, R3 and R4 are H or benzyl; R2 is H or acetyl).

USE: A synthetic intermediate for ganglioside GM3.

PREPARATION: A sialic acid derivative shown by formula II (Bn is benzyl; Ac is acetyl; Ph is phenyl) is reacted with a lactose derivative shown by formula III in the presence of a glycosylating catalyst (e.g. AgOSO2CF3 or AgClO4) preferably in the presence of a solvent such as nitromethane or toluene at -30 to 60°C for 30 minutes to 18 hours to give a compound shown by formula I wherein groups R1, R3 and R4 are benzyl and R2 is H.


Inventors:
NUMATA MASAAKI
SUGIMOTO MAMORU
TOMITA KENKICHI
TANAKA MAKOTO
OGAWA TOMOYA
ITO YUKINARI
Application Number:
JP1989000251287
Publication Date:
May 14, 1991
Filing Date:
September 27, 1989
Export Citation:
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Assignee:
KANTO ISHI PHARMA CO LTD
International Classes:
C07H15/04; C07H15/10; C07H15/14; (IPC1-7): C07H15/04; C07H15/10; C07H15/14