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Title:
GLYCEROL DERIVATIVES,MANUFACTURE AND DRUG CONTAINING THEM
Document Type and Number:
Japanese Patent JPS61293954
Kind Code:
A
Abstract:
Glycerol derivatives of the formula I wherein one of the residues R1, R2 and R3 is a group U of the formula OY1 or -X1-CO-(A1)n-Z1, another residue is a group V of the formula OY2 or -X2-CO-(A2)p-Z2, and the remaining residue is a group W of the formula -X3T-(C2-6-alkylene)-N+R A- in which one of X1, X2 and X3 is oxygen or NQ1 and the other two are oxygen and the remaining symbols have the significance given below, and their hydrates are described and are prepared by introducing or generating the residues R1, R2 and R3 in corresponding glycerol derivatives. The compounds of formula I are active as inhibitors of blood platelet activating factor or as inhibitors of the growth of tumors.

Inventors:
RICHIYAADO BAANAA
KASUPARU BURI
JIYAN MARII KASARU
PAURU HATOBARII
JIYORUJIYU IRUTO
KURAUSU MIYURAA
Application Number:
JP13940586A
Publication Date:
December 24, 1986
Filing Date:
June 17, 1986
Export Citation:
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Assignee:
HOFFMANN LA ROCHE
International Classes:
A61K31/16; A61K31/165; A61K31/17; A61K31/215; A61K31/22; A61K31/265; A61K31/27; A61K31/415; A61K31/445; A61P9/00; A61P9/08; A61P9/10; A61P9/12; A61P11/00; A61P29/00; A61P35/00; A61K31/14; A61P37/08; A61P43/00; C07C67/00; C07C213/00; C07C217/08; C07C233/18; C07C239/00; C07C271/08; C07C271/20; C07C275/10; C07D233/61; C07D277/22; C07D295/08; C07D295/088; C07D521/00; (IPC1-7): A61K31/14; A61K31/16; A61K31/165; A61K31/17; A61K31/215; A61K31/22; A61K31/265; A61K31/27; A61K31/415; A61K31/445; C07C93/02; C07C103/38; C07C125/065; C07C127/15; C07D233/61; C07D295/08
Attorney, Agent or Firm:
Heikichi Odashima