Title:
グリコシル化エンケファリン薬
Document Type and Number:
Japanese Patent JP2006518759
Kind Code:
A
Abstract:
It is taught here that enkephalin peptides which are glycosylated with a disaccharide will be transported across the blood brain barrier and deliver analgesic effects superior to morphine when introduced into the bloodstream. Glycosylated peptides with disaccharides attached are superior to analogous peptides with either mono- or tri-saccharides attached.
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Inventors:
Porto Robin El
Birski Edward Jay
Birski Edward Jay
Application Number:
JP2006503815A
Publication Date:
August 17, 2006
Filing Date:
February 24, 2004
Export Citation:
Assignee:
The Arizona Board of Regents on Behalf of the University of Arizona
International Classes:
C07K14/70; A61K9/00; A61K9/08; A61K38/00; A61P25/04; A61P29/00; C07H5/06; C07H7/00; C07H9/00; C07K7/00; C07K9/00; A61K
Other References:
JPN6009068335, Ｄｒｕｇｓ ｏｆ ｔｈｅ Ｆｕｔｕｒｅ，２００１，２６（６），ｐ．５６１−７６
JPN5006002283, ＥＬＭＡＧＢＡＲＩ, ＦＡＳＥＢ Ｊ．, 20010308, Ｖ１５ Ｎ５, Ｐ． Ａ９１５ ＡＢＳＴＲＡＣＴ ＃７１１．１, ＦＥＤＥＲＡＴＩＯＮ ＯＦ ＡＭＥＲＩＣＡＮ ＳＯＣ． ＦＯＲ ＥＸＰＥＲ． ＢＩＯＬ．
JPN6009068337, Ｊ．Ｏｒｇ．Ｃｈｅｍ．，２００１，６６（７），ｐ．２３２７−４２
JPN5006002283, ＥＬＭＡＧＢＡＲＩ, ＦＡＳＥＢ Ｊ．, 20010308, Ｖ１５ Ｎ５, Ｐ． Ａ９１５ ＡＢＳＴＲＡＣＴ ＃７１１．１, ＦＥＤＥＲＡＴＩＯＮ ＯＦ ＡＭＥＲＩＣＡＮ ＳＯＣ． ＦＯＲ ＥＸＰＥＲ． ＢＩＯＬ．
JPN6009068337, Ｊ．Ｏｒｇ．Ｃｈｅｍ．，２００１，６６（７），ｐ．２３２７−４２
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama