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Document Type and Number:
Japanese Patent JP3430318
Kind Code:

PURPOSE: To provide halistatin 1 which is useful as a material for anticancer drugs.
CONSTITUTION: Halistatin 1 is shown by the formula. This compound is obtained from the sponge Phkellia-carteri gathered in the west Indian Ocean by extracting with methanol-dichloromethane and distributing between hexane-dichloromethane. The yield is 8.8×10-7%. It causes accumulation of cells arrested in mitosis, inhibits tubulin polymerization, inhibits the binding of radiolabeled vinblastine and GTP to tubulin and exerts an ED50 of 4×10-4 μg/ml to P388 cell line of NCI based on NCI protocol. Halistin 1 suppresses the growth of tumor cells of such as leukemia, non-small-cell lung cancer, small cell lung cancer, colic cancer, CNS cancer, melanoma, ovarian cancer and kidney cancer.

Pettit, George R.
Tan, Rui
Gao, Feng
Application Number:
Publication Date:
July 28, 2003
Filing Date:
January 17, 1994
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Univ, Arizona Found
International Classes:
A61K31/365; A61K35/00; A61K35/02; A61K35/56; A61P35/00; A61P35/02; C07D493/22; C07H9/02; C12P17/18; C12P19/44; (IPC1-7): C07D493/22; A61K31/365; A61K35/00; A61K35/02
Other References:
Pure. & Appl. Chem.,Vol.58,No.5(1986年)P.701−710
Attorney, Agent or Firm:
桑原 尚雄

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