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Title:
HETEROALKYL-SUBSTITUTED PHENYLALKYLAMINE DERIVATIVE
Document Type and Number:
Japanese Patent JPH09169709
Kind Code:
A
Abstract:

To obtain the subject derivative having an antipsychotic action without causing extrapyramidal disorders, and useful for treating schizophrenia, cerebrovascular disorder, and trouble behaviors on geriatric dementia.

This heteroalkyl-substituted phenylalkylamine derivative of formula I [X is H, a halogen, etc. ; Y is O, S, SO2; R1, R2 are each H, a 1-7C alkyl, etc.; R3 is a 1-5C alkyl, etc.; Ar is phenyl, thienyl, etc.; (n) is an integer of 2-5], e.g. 1-ethoxymethyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine hydrochloride. The derivative of formula I is obtained e.g. from an aldehyde of formula II as a starting raw material through a condensation reaction, a hydrolysis reaction, a decarbonization reaction, a Curtius rearrangement reaction, a reduction reaction, etc.


Inventors:
NAKAZATO ATSUO
AIBE IZUMI
TOMIZAWA KAZUYUKI
Application Number:
JP1995000333248
Publication Date:
June 30, 1997
Filing Date:
December 21, 1995
Export Citation:
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Assignee:
TAISHO PHARMA CO LTD
International Classes:
C07D333/16; A61K31/135; A61K31/38; A61K31/381; A61P25/18; C07C217/64; C07C317/28; C07C323/29; (IPC1-7): C07C217/64; A61K31/135; A61K31/38; C07C317/28; C07C323/29; C07D333/16
Attorney, Agent or Firm:
北川 富造