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Title:
複素環キナーゼ阻害剤
Document Type and Number:
Japanese Patent JP2012503655
Kind Code:
A
Abstract:
The present invention provides heterocyclic compounds for use as kinase inhibitors and in other applications. Also provided are pharmaceutical compositions and methods of treatments of diseases and conditions associated with P13 kinase activity.

Inventors:
Len, pinda
Liu
Lee, Liang Shen
Chan, Katrina
Wilson, Troy Edward
Application Number:
JP2011529032A
Publication Date:
February 09, 2012
Filing Date:
September 28, 2009
Export Citation:
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Assignee:
Intellica Inn, Inc.
International Classes:
C07D487/04; A61K31/519; A61K31/5377; A61K45/00; A61P9/00; A61P11/06; A61P17/02; A61P19/02; A61P29/00; A61P35/00; A61P35/02; A61P37/00; A61P43/00; C07D519/00
Domestic Patent References:
JP2004115450A2004-04-15
JP2006504669A2006-02-09
JP2007520559A2007-07-26
JP2006506341A2006-02-23
JP2006515597A2006-06-01
JP2005500295A2005-01-06
JP2008534609A2008-08-28
JP2002507996A2002-03-12
JP2004115450A2004-04-15
JP2006504669A2006-02-09
JP2008534689A2008-08-28
JP2007520559A2007-07-26
JP2006506341A2006-02-23
JP2006515597A2006-06-01
JP2005500295A2005-01-06
JP2008534609A2008-08-28
JP2002507996A2002-03-12
Foreign References:
WO2005063738A12005-07-14
WO2001002400A12001-01-11
WO2002002550A12002-01-10
WO2007117465A22007-10-18
WO2007056468A12007-05-18
WO2007081030A12007-07-19
WO2007054294A12007-05-18
WO2008118454A22008-10-02
WO2009097446A12009-08-06
WO2005063738A12005-07-14
WO2001002400A12001-01-11
WO2002002550A12002-01-10
WO2007117465A22007-10-18
WO2007056468A12007-05-18
WO2007081030A12007-07-19
WO2007054294A12007-05-18
WO2008118454A22008-10-02
WO2008118468A12008-10-02
WO2009097446A12009-08-06
WO2002085905A12002-10-31
Other References:
JPN6014003500; Ｐｒｏｃｅｅｄｉｎｇｓ　ｏｆ　ｔｈｅ　Ｎａｔｉｏｎａｌ　Ａｃａｄｅｍｙ　ｏｆ　Ｓｃｉｅｎｃｅｓ　ｏｆ　ｔｈｅ　Ｕｎｉｔｅｄ　Ｓｔａｔｅｓ　ｏｆ　Ａｍｅｒｉｃａ Ｖｏｌ．１０３，　Ｎｏ．５２, 2006, ｐｐ．１９８６６-１９８７１，　Ｓｕｐｐｏｒｔｉｎｇ　Ｉｎｆｏｒｍａｔｉｏｎ
JPN6014003499; Ｂｉｏｏｒｇａｎｉｃ　＆　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ　Ｌｅｔｔｅｒｓ Ｖｏｌ．１７，　Ｎｏ．６, 2007, ｐｐ．１７３６-１７４０
JPN6014003500; Ｐｒｏｃｅｅｄｉｎｇｓ　ｏｆ　ｔｈｅ　Ｎａｔｉｏｎａｌ　Ａｃａｄｅｍｙ　ｏｆ　Ｓｃｉｅｎｃｅｓ　ｏｆ　ｔｈｅ　Ｕｎｉｔｅｄ　Ｓｔａｔｅｓ　ｏｆ　Ａｍｅｒｉｃａ Ｖｏｌ．１０３，　Ｎｏ．５２, 2006, ｐｐ．１９８６６-１９８７１，　Ｓｕｐｐｏｒｔｉｎｇ　Ｉｎｆｏｒｍａｔｉｏｎ
JPN6014003499; Ｂｉｏｏｒｇａｎｉｃ　＆　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ　Ｌｅｔｔｅｒｓ Ｖｏｌ．１７，　Ｎｏ．６, 2007, ｐｐ．１７３６-１７４０
JPN6014036274; ＩＳＯＢＥ，Ｙ．　ｅｔ　ａｌ: 'Ｓｙｎｔｈｅｓｉｓ　ａｎｄ　Ｂｉｏｌｏｇｉｃａｌ　Ｅｖａｌｕａｔｉｏｎ　ｏｆ　Ｎｏｖｅｌ　９-Ｓｕｂｓｔｉｔｕｔｅｄ-８-Ｈｙｄｒｏｘｙａｄｅｎｉｎｅ　Ｄｅｒｉｖａｔｉｖｅｓ　ａｓ　Ｐｏｔｅｎｔ　Ｉｎ' Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．４９，　Ｎｏ．６, 2006, ｐｐ．２０８８-２０９５
JPN6014036275; ＲＡＢＯＩＳＳＯＮ，Ｐ．　ｅｔ　ａｌ: 'Ｄｅｓｉｇｎ，　ｓｙｎｔｈｅｓｉｓ　ａｎｄ　ｓｔｒｕｃｔｕｒｅ-ａｃｔｉｖｉｔｙ　ｒｅｌａｔｉｏｎｓｈｉｐｓ　ｏｆ　ａ　ｓｅｒｉｅｓ　ｏｆ　９-ｓｕｂｓｔｉｔｕｔｅｄ　ａｄｅｎｉｎｅ　ｄｅｒｉｖａｔｉ' Ｅｕｒｏｐｅａｎ　Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．３８，　Ｎｏ．２, 2003, ｐｐ．１９９-２１４
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita



 
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