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Title:
MHCクラスIIと糖尿病関連自己抗原性ペプチドとの天然型複合体に対するT細胞受容体様特異性を有する単離された高親和性実体
Document Type and Number:
Japanese Patent JP2013535963
Kind Code:
A
Abstract:
Provided are isolated complexes comprising a major histocompatibility complex (MHC) class II and a type I diabetes-associated autoantigenic peptide, the isolated complex having a structural conformation which enables isolation of a high affinity entity which comprises an antigen binding domain capable of specifically binding to a native conformation of a complex composed of the MHC class II and the type I diabetes-associated autoantigenic peptide; and isolated high affinity entities comprising an antigen binding domain capable of specifically binding the complex, wherein the isolated high affinity entity does not bind to the MHC class II in an absence of the diabetes-associated autoantigenic peptide, wherein the isolated high affinity entity does not bind to the diabetes-associated autoantigenic peptide in an absence of the MHC class II; and methods and kits using same for diagnostic and therapeutic purposes.

Inventors:
Leytel, Yoram
Ronnie, Dahan
Application Number:
JP2013519215A
Publication Date:
September 19, 2013
Filing Date:
July 14, 2011
Export Citation:
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Assignee:
TECHNION RESEARCH AND DEVELOPMENT FOUNDATION LTD.
International Classes:
C12N15/09; A61K39/395; A61K45/00; A61P3/10; C07K14/47; C07K14/74; C07K16/28; C07K19/00; C12Q1/02; G01N33/564; C12P21/08
Domestic Patent References:
JP2001516571A2001-10-02
JP2008537736A2008-09-25
Foreign References:
WO2004007528A22004-01-22
Other References:
JPN6015035667; J. Autoimmun. Vol.25, 2005, P.235-243
JPN6015035670; Proc. Natl. Acad. Sci. USA Vol.98, No.4, 2001, P.1763-1768
JPN6015035664; Proc. Natl. Acad. Sci. USA Vol.97, No.26, 2000, P.14596-14601
JPN6015035661; J. Immunol. Vol.183, No.7, 2009, P.4809-4816
Attorney, Agent or Firm:
Nobuaki Kazehaya
Noriko Asano