Title:
ヒストンデアセチラーゼ阻害剤
Document Type and Number:
Japanese Patent JP5409015
Kind Code:
B2
Abstract:
In recognition of the need to develop novel therapeutic agents, the present invention provides novel histone deacetylase inhibitors. These compounds include an ester bond making them sensitive to deactivation by esterases. Therefore, these compounds are particularly useful in the treatment of skin disorders. When the compounds reaches the bloodstream, an esterase or an enzyme with esterase activity cleaves the compound into biologically inactive fragments or fragments with greatly reduced activity Ideally these degradation products exhibit a short serum and/or systemic half-life and are eliminated rapidly. These compounds and pharmaceutical compositions thereof are particularly useful in treating cutaneous T-cell lymphoma, neurofibromatosis, psoriasis, hair loss, skin pigmentation, and dermatitis, for example. The present invention also provides methods for preparing compounds of the invention and intermediates thereto.
Inventors:
Shriver, Stewart El.
Bradner, James Elliott
MAGIC CHECK, Ralph
Bradner, James Elliott
MAGIC CHECK, Ralph
Application Number:
JP2008555472A
Publication Date:
February 05, 2014
Filing Date:
February 14, 2007
Export Citation:
Assignee:
President and Fellows of Harvard College
International Classes:
C07C239/18; A61K31/222; A61K31/422; A61P17/00; A61P17/06; A61P29/00; A61P35/00; A61P43/00; C07D413/12
Domestic Patent References:
| JP2007522234A | ||||
| JP2003509343A | ||||
| JP2002535382A | ||||
| JP2002531576A |
Other References:
Angewandte Chemie, International Edition,2001年,40(20),3905-3907
J.Nat.Prod.,2003年,66,1338-1344
化学大辞典1,1960年,377
J.Nat.Prod.,2003年,66,1338-1344
化学大辞典1,1960年,377
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita