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Title:
ヒストンデアセチラーゼおよびチューブリンデアセチラーゼ阻害剤
Document Type and Number:
Japanese Patent JP2009535405
Kind Code:
A
Abstract:
In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel inhibitors of histone deacetylases, tubulin deacetylases, and/or aggresome inhibitors, and pharmaceutically acceptable salts and derivatives thereof. The inventive compounds fall into two classes—isotubacin class and isoisotubacin class—all of which include a 1,3-dioxane core. The present invention further provides methods for treating disorders regulated by histone deacetylase activity, tubulin deacetylase activity, and/or the aggresome (e.g., proliferative diseases, cancer, inflammatory diseases, protozoal infections, protein degradation disorders, protein deposition disorders, etc.) comprising administering a therapeutically effective amount of an inventive compound to a subject in need thereof. The present invention also provides methods for preparing compounds of the invention.

Inventors:
Mazitshek, Ralph
Kwiatkowski, Nicholas Paul
Bradner, James Elliott
Application Number:
JP2009509675A
Publication Date:
October 01, 2009
Filing Date:
May 02, 2007
Export Citation:
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Assignee:
President and Fellows of Harvard College
International Classes:
C07D319/06; A61K31/357; A61K31/422; A61K31/428; A61K31/4433; A61K45/00; A61P25/28; A61P29/00; A61P31/00; A61P35/00; A61P43/00; C07D405/12; C07D413/12; C07D417/12
Domestic Patent References:
JP2009526864A2009-07-23
Other References:
JPN6012057541; SAIKACHI,H. et al: Journal of the American Chemical Society Vol.80, 1958, p.3642-3645
JPN6012057543; HAGGARTY,S.J. et al: Proceedings of the National Academy of Science of the United States of America Vol.100, No.8, 2003, p.4389-4394
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita



 
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