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Title:
マラリア原虫のGPIの生合成を阻害する化合物をスクリーニングする方法
Document Type and Number:
Japanese Patent JP2006506996
Kind Code:
A
Abstract:
The present inventors succeeded in isolating GWT1 (PfGWT1), which is one of the enzymes involved in GPI biosynthesis in the malaria parasite P. falciparum. In addition, the inventors revealed that degenerate mutant DNAs, with a lower AT content than the DNA encoding the PfGWT1 protein, can complement the phenotype of GWT1-deficient yeast. Based on the findings, the present invention provides the GWT1 protein of malaria parasites and the use of the protein in methods of screening for antimalarial drugs. The present invention also provides degenerate mutant DNAs encoding proteins involved in GPI biosynthesis, and which have a lower AT content than the original DNAs. The present invention also provides methods of screening for antimalarial drugs which use the degenerate mutant DNAs.

Inventors:
Katsura
Kaoru Ogawa
Takashi Tsukada
Kazutaka Nakamoto
Aiji Koji
Keigo Tanaka
Katsuhei Tsukahara
Toshihiro Horii
Application Number:
JP2004555010A
Publication Date:
March 02, 2006
Filing Date:
November 21, 2003
Export Citation:
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Assignee:
EISAI CO.,LTD.
International Classes:
C12N15/09; A61K31/44; A61K31/472; A61K45/00; A61P33/06; C07K14/445; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/10; C12Q1/02; C12Q1/18; C12Q1/48; G01N33/15; G01N33/50; G01N33/573; C07D213/65; C07D213/74; C07D217/18; C07D217/20
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi