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Title:
【発明の名称】プロサポシン受容体活性を刺激する方法
Document Type and Number:
Japanese Patent JP2002524468
Kind Code:
A
Abstract:
A method for stimulating prosaposin receptor activity in a cell by transfecting the cell with a DNA or RNA molecule encoding prosaposin or a prosaposin receptor agonist. The DNA or RNA molecule is administered either in vivo or used to transfect neural cells or neural stem cells ex vivo followed by reintroduction of the cells into an individual.

Inventors:
O'Brien John S
Parkes De Elliott
Application Number:
JP2000568870A
Publication Date:
August 06, 2002
Filing Date:
September 09, 1999
Export Citation:
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Assignee:
Myelos corporation
International Classes:
A61K9/48; A61K31/7105; A61K31/711; A61K35/76; A61K38/00; A61K38/18; A61K45/00; A61K48/00; A61P9/10; A61P21/00; A61P25/02; A61P25/28; A61P27/02; A61P43/00; C07K1/14; C12N15/09; C07K14/00; C07K14/47; C12N5/10; C07K; (IPC1-7): A61K48/00; A61K9/48; A61K31/7105; A61K31/711; A61P9/10; A61P21/00; A61P25/02; A61P25/28; A61P27/02; A61P43/00; C07K14/47; C12N5/10; C12N15/09
Domestic Patent References:
JPH09503999A1997-04-22
Other References:
JPN6009052550; RAFI,M.A. et al, Correction of sulfatide metabolism after transfer of prosaposin cDNA to cultured ce
JPN6009052553; HIRAIWA,M. et al, Isolation, characterization, and proteolysis of human prosaposin, the precursor of
JPN6013011322; 中村晴臣: 'ロイコジストロフィーの病理' 脳と発達 第19巻第2号, 19870301, 第97〜105頁
JPN6013012674; 桜川宣男: '神経疾患の遺伝子治療' 実験医学 第12巻第15号(増刊), 1994, 第102-107頁
JPN6013012681; Eliav Barr et al: 'Systemic Delivery of Recombinant Proteins by Genetically Modified Myoblasts' American Association for the Advancement of Science Vol.254, 19911206, p1507-1509
JPN6013012679; 大橋十也: 'リソソーム蓄積症の遺伝子治療' 実験医学 第12巻第15号(増刊), 1994, 第88-95頁
Attorney, Agent or Firm:
Takao Suzuki (4 others)