Title:
【発明の名称】組織エンジニアリングのための改良されたヒドロゲル
Document Type and Number:
Japanese Patent JP2001517494
Kind Code:
A
Abstract:
This invention provides compositions for use in implanting into an animal comprising a biodegradable, biocompatible polymer which forms a hydrogel upon cross-linking. In a preferred mode, the polymer is cross-linked by multivalent ions; more preferably, a soluble salt of a multivalent ion and a sparingly soluble salt of a multivalent ion, these components being combined into a mixture which forms a partially hardened, injectable hydrogel, the consistency of the mixture being suitable for implanting the partially hardened hydrogel mixture into the animal, where the implanted, partially hardened hydrogel forms in situ a fully hardened hydrogel. Preferably, the mixture also contains a biocompatible sequestrant which competes with the biocompatible polymer for binding of the multivalent cross-linking ion. The composition may or may not contain living cells. The invention also provides methods for implanting the composition in an animal, optionally as an implant containing living cells.
More Like This:
Inventors:
Borland, Kermit M
Butterfly tao
Nelson, Gordon Pee
Omstead, Daniel Earl
Butterfly tao
Nelson, Gordon Pee
Omstead, Daniel Earl
Application Number:
JP2000512578A
Publication Date:
October 09, 2001
Filing Date:
September 18, 1998
Export Citation:
Assignee:
Reprogenesis Incorporated
International Classes:
A61L27/00; A61L27/20; A61L27/38; A61L27/52; A61L31/00; A61L31/14; (IPC1-7): A61L27/00; A61L31/00
Attorney, Agent or Firm:
Kazuo Shamoto (5 outside)