PURPOSE: To provide new hydroxylamine derivative being effective control factor for biosythesis of leukotrienes and useful as treating agent in the case of treatment of inflammatory diseases intermediated by leukotriens and arthritus.
CONSTITUTION: This derivative is expressed by the formula I (where R4 is H, carbamoyl, alkyl, cyclopentyl, benzoyl, etc.; R5 is H, alkyl, phenyl, etc.; A4 is optionally substd. alkylene; Ar1 is optionally substd. phenylene, pyridinediyl or pyrimidinediyl; A1 is a direct link or alkylene; X1 is O, S SO or SO2; Ar2 is Ar1, thiophenediyl, etc.; R1 is H, alkyl, alkenyl, etc.; R2 and R3 together form the group of the formula A2-X2-A3 (A2 and A3 are alkylene; X2 is X1 or NH), or R1 and R2 together form the group of the formula A2-X2-A3 (X2 is X1), R3 is alkyl, alkenyl, etc.) such as N,N-diethyl-O-(4-(5-fluoro-3-(4- methoxytetrahydropyrane-4-yl)phenylthio)-α-methylbenzyl)hydroxylamine.
MAIKERU SUCHIYUAATO RAAJI
ZENECA PHARMA SA