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Patent Searching and Data


Title:
HYDROXYMETHYL-INDOLIZIDINE OR QUINOLIZIDINE
Document Type and Number:
Japanese Patent JPH04221382
Kind Code:
A
Abstract:

PURPOSE: To provide the subject new compound which is excellent in inhibiting activity to after-meal hyperglycemia as medicaments of diabetes, and has inhibiting activity to α-glucosidase, so that it can be effectively used as an antiviral agent.

CONSTITUTION: This compound is represented by formula I (n) is 1, 2; R1 and R2 are each H, OA4, A and A1-A4 are each H, 1-18C alkanoyl or the like), or a salt thereof, e.g. [5R-(5α, 6β, 7α, 8β, 8aα)] octahydro-6,7,8-trihydroxy-5- hydroxymethylindolizine. Lactam shown by formula III (Bn is phenylmethyl; R3 is R1; (m) is (n)) is reduced with a hydride reducing agent such as aluminum hydride or the like in an inert solvent such as THF or the like, and then the product is hydrogenated to produce the compound of formal I in which A, A1-A4 are each H. The lactam of formula III is prepared by using, e.g. a compound of formula IV (Z is benzyloxycarbonyl or the like) as a starting material.


Inventors:
POORU SEIHO RIYUU
MOUINDAA SHINGU KANGU
ROORANDO SUTEFUAN ROJIYAASU
BAARII RII RAINHAATO
Application Number:
JP8918691A
Publication Date:
August 11, 1992
Filing Date:
March 29, 1991
Export Citation:
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Assignee:
MERRELL DOW PHARMA
International Classes:
A61P3/08; A61P3/10; A61P31/12; A61K31/435; C07D455/02; C07D471/04; (IPC1-7): A61K31/435; C07D455/02; C07D471/04
Attorney, Agent or Firm:
Yataro Sasai (1 person outside)