Title:
【発明の名称】複素環置換チアゾリウム塩を使用する進行したグリコシル化架橋物の逆転
Document Type and Number:
Japanese Patent JP2002529414
Kind Code:
A
Abstract:
The present invention relates to compositions and methods for reversing advanced glycosylation end product-mediated cross-linking and protein aging. Accordingly, compositions are described which comprise thiazolium compounds substituted with heterocyclic groups which are capable of reversing the formation of advanced glycosylation end product cross-links. Both industrial and therapeutic applications for the invention are disclosed, as food spoilage and animal protein aging can be treated. Such compounds have particular application in the treatment of protein aging such as is responsible for the complications of aging and diabetes.
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Inventors:
Waggle, dirip
Fan, shen, din
Law, Tykyun
Eagan, John, Jay
Ulrich, Peter
Cerami, Anthony
Fan, shen, din
Law, Tykyun
Eagan, John, Jay
Ulrich, Peter
Cerami, Anthony
Application Number:
JP2000580624A
Publication Date:
September 10, 2002
Filing Date:
November 10, 1999
Export Citation:
Assignee:
Alteon Incorporated
International Classes:
C07D277/20; A61K8/00; A61K8/49; A61K31/426; A61K31/427; A61K31/431; A61K31/4439; A61K31/454; A61K31/4709; A61K31/496; A61K31/5355; A61K31/5377; A61K31/541; A61K31/55; A61P9/14; A61P13/12; A61P17/00; A61P27/02; A61Q19/00; C07D277/22; C07D277/24; C07D277/44; C07D417/06; (IPC1-7): C07D417/06; A61K7/00; A61K7/48; A61K31/431; A61K31/4439; A61K31/454; A61K31/4709; A61K31/496; A61K31/5377; A61K31/541; A61K31/55; A61P9/14; A61P13/12; A61P17/00; A61P27/02; C07D277/20; C07D277/22
Foreign References:
| WO1996022095A2 | 1996-07-25 | |||
| WO1997009981A1 | 1997-03-20 |
Attorney, Agent or Firm:
Katsuro Sasai