To obtain an excellent ileum-type bile acid transporter inhibitor containing a cyclobutene derivative, a pharmacologically acceptable salt thereof, or an ester or other derivative thereof.
This ileum-type bile acid transporter inhibitor contains the cyclobutene derivative represented by formula (I) [wherein, R1 is a cycloalkyl, an aryl, a heterocycle, or the like; R2 is a cycloalkyl, an aryl, a heterocycle, or the like; R3 and R4 are each hydrogen atom, or the like; A is represented by formula (A-1) (wherein, R5 is hydrogen atom, or the like; R6 is an amine residue, or the like; X and Y are each oxygen atom, or the like; and Z is a single bond, or the like); G is an alkylene group, or the like; when the broken line is a double bond, D is carbon atom, and E is a group having =N-O-; when the broken line is a single bond, D is a group having CH, or the like, and E is a group having NH, or the like], the pharmacologically acceptable salt thereof, or the ester or other derivative thereof.
| WO/2008/017824 | BICYCLO [2. 2. 1] HEPT-7-YLAMINE DERIVATIVES AND THEIR USE |
| JP2009531322 | Antibacterial agent |
FURUHAMA TAKAFUMI
KOUNO KEITA
KITAYAMA TAKESHI
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