IMPROVED MANUFACTURE OF 2_BETA_D_RIBOFLANOSYL SELENAZOLE_4_CARBOXAMIDE

Title:

IMPROVED MANUFACTURE OF 2_BETA_D_RIBOFLANOSYL SELENAZOLE_4_CARBOXAMIDE

Document Type and Number:

Japanese Patent JPS6136293

Kind Code:

A

Abstract:

A chemical process for preparing 2-β-D-ribofuranosylse- lenazole-4-carboxamide, comprises the steps of:a) reacting 2,3,5-tri-O-benzoyl-β-D-ribofuranosyl-1-carbonitrile with gaseous hydrogen selenide, preferably in a 1:1 to 1:1.5 molar ratio, at a temperature and for a period sufficient to effect conversion of said 2,3,5-tri-O-benzoyl-β-D--ribofuranosyl-1-carbonitrile to 2,5-anhydro-3,4,6-tri-O--benzoyl-β-D-allonselenocarboxamide;b) reacting said 2,5-anhydro-3,4,6-tri-O-benzoyl-β-D-allonselenocarboxamide with ethyl bromopyruvate to produce ethyl 2-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)selenazole-4-carboxylate; andc) thereafter converting said ethyl 2-(2,3,5-tri-O-benzoyl-β--B-ribofuranosyl)selenazole-4-carboxylate to 2-β-D-ribo- furanosylselenazole-4-carboxamide.

Inventors:

PII DAN KUTSUKU
DENISU JIEI MAKUNAAMARA

Application Number:

JP14845385A

Publication Date:

February 20, 1986

Filing Date:

July 08, 1985

Export Citation:

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Assignee:

WARNER LAMBERT CO

International Classes:

C07H9/06; C07D307/24; C07D421/04; C07D307/18; (IPC1-7): C07H9/06

Attorney, Agent or Firm:

Chika Takagi

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