Title:
改善された治療薬物モニタリング
Document Type and Number:
Japanese Patent JP7209644
Kind Code:
B2
Abstract:
Disclosed herein are methods and compositions for antimicrobial quantification and functional measurement. In one aspect, a method for quantifying antimicrobial comprises: obtaining a biological sample from a patient receiving an antimicrobial; incubating the biological sample with a reference microbial strain and a fluorophore for detecting cell lesion; measuring a first signal of fluorescent intensity in the incubated biological sample using flow cytometry; and comparing the first signal to a calibrating curve previously generated for the antimicrobial, thereby quantifying the antimicrobial present in the biological sample.
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Inventors:
Azevedo Pina Vaz, Sydalia Irene
Goncalves Rodriguez, Acacio Agostigne
Goncalves Rodriguez, Acacio Agostigne
Application Number:
JP2019566649A
Publication Date:
January 20, 2023
Filing Date:
June 01, 2018
Export Citation:
Assignee:
Fast Inobu S.A.
International Classes:
C12Q1/06; G01N33/48
Domestic Patent References:
JP5038298A | ||||
JP2016536592A | ||||
JP2014515276A | ||||
JP60500557A | ||||
JP9511150A |
Foreign References:
CN105916994A | ||||
US20150056648 |
Other References:
Chemotherapy, 1993, Vol.41, pp.135-141
PLOS ONE, 2016, Vol.11, No.3, e0151694 (pp.1-15)
Int. J. Antimicrob. Agents, 2015, Vol.46, pp.367-375
PLOS ONE, 2016, Vol.11, No.3, e0151694 (pp.1-15)
Int. J. Antimicrob. Agents, 2015, Vol.46, pp.367-375
Attorney, Agent or Firm:
Shusaku Yamamoto
Morishita Natsuki
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Morishita Natsuki
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto