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Title:
INDOLE DERIVATIVE
Document Type and Number:
Japanese Patent JPS63146874
Kind Code:
A
Abstract:
The invention relates to compounds of formula (I) wherein R<1> represents a hydrogen atom or a group selected from C1-10 alkyl, C3-6 alkenyl, C3-10 alkynyl, C3-7 cycloalkyl, C3-7 cycloalkyl C1-4 alkyl, phenyl, or phenyl C1-3alkyl, -CO2R<1><0>, -COR<1><0>, -CONR<1><0>R<1><1> or -SO2R<1><0> (wherein R<1><0> and R<1><1>, which may be the same or different , each represents a hydrogen atom, a C1-6 alkyl or C3-7 cycloalkyl group, or a phenyl or phenylC1-4 alkyl group, in which the phenyl group is optionally substituted by one or more C1-4 alkyl, C1-4 alkoxy or hydroxy groups or halogen atoms, with the proviso that R<1><0> does not represent a hydrogen atom when R<1> represents a group -CO2R<1><0> or -SO2R<1><0>); R2 represents a hydrogen atom or a C1-6 alkyl, C3-6 alkenyl, C3-7 cycloalkyl, phenyl or phenyl C1-3 alkyl group; R3 and R4, which may be the same of different, each represents a hydrogen atom or a C1-6 alkyl group; One of the groups represented by R<5>, R<6> and R<7> is a hydrogen atom or a C1-6 alkyl, C1-6 hydroxyalkyl, C3-7 cycloalkyl, C2-6 alkenyl, phenyl or phenyl C1-3 alkyl group, and each of the other two groups, which may be the same or different, represents a hydrogen atom or a C1-6 alkyl group; and Q represents a hydrogen or a halogen atom, or a hydroxy, C1-4 alkoxy, phenyl C1-3 alkoxy or C1-6 alkyl group or a group -NR<8>R<9> or -CONR<8>R<9> wherein R<8> and R<9>, which may be the same or different, each represents a hydrogen atom or a C1-4 alkyl or C3-4 alkenyl group, or together with the nitrogen atom to which they are attached form a saturated 5 to 7 membered ring; and physiologically acceptable salts and solvates thereof. The compounds are potent and selective antagonists of the effect of 5-HT at 5-HT3 receptors and are useful, for example, in the treatment of psychotic disorders, anxiety, and nausea and vomiting.

Inventors:
DEIBITSUDO SEDORITSUKU HANBAA
IAN HARORUDO KOOTEIZU
JIEEMUZU ANGASU BERU
JIYOOJI BURANCHI IIWAN
Application Number:
JP24965387A
Publication Date:
June 18, 1988
Filing Date:
October 02, 1987
Export Citation:
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Assignee:
GLAXO GROUP LTD
International Classes:
A61K31/415; A61P43/00; C07D403/06; C07D209/12; C07D521/00; (IPC1-7): A61K31/415; C07D209/12; C07D403/06



 
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