INTERMEDIATE FOR PRODUCING NEW CEPHALOSPORIN CONTAINING SUBSTITUTED BENZYLOXIMINO GROUP AT 7-POSITION

Title:

INTERMEDIATE FOR PRODUCING NEW CEPHALOSPORIN CONTAINING SUBSTITUTED BENZYLOXIMINO GROUP AT 7-POSITION

Document Type and Number:

Japanese Patent JP3288951

Kind Code:

B2

Abstract:

PROBLEM TO BE SOLVED: To obtain a new compound useful as an intermediate for producing a new cephalosporin antibiotic having a substituted benzyloximino group at the 7-position, exhibiting high antibacterial activities against gram-positive bacteria and gram-negative bacteria and effective for penicillin-resistant staphylococci.
SOLUTION: This new 2-aminothiazol derivative is expressed by formula I [R1p-R5p are each a (protected)R1-a (protected)R5 (R1-R2 are each H, a halogen, OH, a 1-4C alkyl, a 1-4C alkyloxy, SH, a 1-4C alkylthio, nitro cyano, amino, etc.,); R7 is an easily cleavable easter residue; R8 is H, a group for protecting an amino functional group], etc., and is useful as an intermediate for producing a new cephalosporin containing a substituted benzyloximino group at the 7-position, represented by formula II (R6 is a heterocyclic group of quaternary ammonium form) and useful as an antibiotic having highly good antibacterial activities against gram-positive bacteria such as penicillin-resistant staphylococci and also effective for gram-negative bacteria.

Inventors:

Joseph Azodi
Jean Francois Shunt
Patrick Forbo
Solange Gouin d'Ambriere
Daniel Amber

Application Number:

JP8241497A

Publication Date:

June 04, 2002

Filing Date:

March 17, 1997

Export Citation:

Click for automatic bibliography generation Help

Assignee:

Hoechst Marion Roussel

International Classes:

A61K31/546; A61P31/04; C07C45/63; C07C45/67; C07C45/71; A61K31/545; C07C47/565; C07C47/575; C07C59/48; C07C59/64; C07C69/734; C07C205/44; C07C229/40; C07C239/08; C07C239/20; C07C255/56; C07C255/57; C07C291/02; C07C311/27; C07C311/35; C07C323/52; C07C323/56; C07D277/20; C07D277/40; C07D277/42; C07D501/00; C07D501/04; C07D501/06; C07D501/24; C07D501/46; C07D501/56; C07D519/06; (IPC1-7): C07D501/56; C07D501/24; C07D519/06

Domestic Patent References:

JP334986A
JP62161793A
JP6089487A
JP63166837A
JP4261185A
JP4230289A

Other References:

【文献】米国特許3619187(US,A)

Attorney, Agent or Firm:

Motohiro Kurauchi (1 outside)

Previous Patent: SYSTEM FOR MONITORING TIME-OUT OF BUS USE REQUEST

Next Patent: COIN PROCESSING MACHINE