PURPOSE: To obtain the subject new compound, capable of efficiently introducing new carboxyl group into a compound to be acylated under mild conditions and useful as an acylating agent for various alcoholic hydroxyl groups or thiol groups.
CONSTITUTION: A compound expressed by formula I [R is H or carboxylic acid-protecting group; (n) is 1-7], e.g. benzyl isopropenyl succinate. This compound is obtained by reacting, e.g. a compound expressed by formula II with an isopropenyl ester of an organic acid in the presence of mercury acetate or an acidic catalyst at 20-40°C. Isopropenyl acetate is preferred as the isopropenyl ester of the organic acid. The raw material compound expressed by formula II is obtained by carrying out a method for reacting, e.g. the corresponding organic acid anhydride with an alcohol, etc. For example, boron trifluoride.etherate is used as the acidic catalyst.
MAEDA HIROSHI