Title:
ＫＩＦ１８Ａ阻害剤
Document Type and Number:
Japanese Patent JP2022513972
Kind Code:
A
Abstract:
ＫＩＦ１８Ａタンパク質を調節し、それにより細胞周期及び細胞増殖のプロセスに影響を及ぼしてがん及びがん関連疾患を治療することができる、本明細書で定義される式（Ｉ）の化合物、及びその合成中間体。本発明は、化合物を含む医薬組成物、及びＫＩＦ１８Ａの活性に関連する病状を治療する方法も含む。TIFF2022513972000145.tif36170
Inventors:
Tamayo, Nuria A
Banazi, Abishek
Brown, James Alexander
Frohn, Michael Jay
Chen, Jian Jeffrey
Lee, Kirshwe
Liu, Ching Yen
Rowe, Jonathan Dante
Ma, Boo
Petas, Ripping H
Walton, Mary Katherine
Minatti, Anna Elena
Bourbo, Matthew Paul
Zia, Ray
Banazi, Abishek
Brown, James Alexander
Frohn, Michael Jay
Chen, Jian Jeffrey
Lee, Kirshwe
Liu, Ching Yen
Rowe, Jonathan Dante
Ma, Boo
Petas, Ripping H
Walton, Mary Katherine
Minatti, Anna Elena
Bourbo, Matthew Paul
Zia, Ray
Application Number:
JP2021534715A
Publication Date:
February 09, 2022
Filing Date:
December 20, 2019
Export Citation:
Assignee:
Amjien Incorporated
International Classes:
C07D213/74; A61K31/506; A61K31/5377; A61K31/541; A61P35/00; A61P35/02; A61P43/00; C07D401/12; C07D401/14; C07D405/14; C07D413/14; C07D419/14
Domestic Patent References:
| JP2009514866A | 2009-04-09 | |||
| JP2022514268A | 2022-02-10 | |||
| JP2012529470A | 2012-11-22 | |||
| JP2008503501A | 2008-02-07 | |||
| JP2022513967A | 2022-02-09 | |||
| JP2022513971A | 2022-02-09 |
Foreign References:
| WO2015020184A1 | 2015-02-12 | |||
| WO2011085261A1 | 2011-07-14 |
Other References:
GIRGIS, A. S. ET AL.: "Novel synthesis of nicotinamide derivatives of cytotoxic properties", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 14, no. 13, JPN6022029965, 2006, pages 4466 - 4476, XP025133347, ISSN: 0005029486, DOI: 10.1016/j.bmc.2006.02.031
JOACHIM BRAUN ET AL.: "Synthesis and Biological Evaluation of Optimized Inhibitors of the Mitotic Kinesin Kif18A", ACS CHEMICAL BIOLOGY, vol. 10, no. 2, JPN6022029966, 17 November 2014 (2014-11-17), pages 554 - 560, XP055671701, ISSN: 0005029487, DOI: 10.1021/cb500789h
JOACHIM BRAUN ET AL.: "Synthesis and Biological Evaluation of Optimized Inhibitors of the Mitotic Kinesin Kif18A", ACS CHEMICAL BIOLOGY, vol. 10, no. 2, JPN6022029966, 17 November 2014 (2014-11-17), pages 554 - 560, XP055671701, ISSN: 0005029487, DOI: 10.1021/cb500789h
Attorney, Agent or Firm:
Kawaguchi International Patent Office
Previous Patent: Heteroarylamide useful as a KIF18A inhibitor
Next Patent: Hot rolled steel and its manufacturing method
Next Patent: Hot rolled steel and its manufacturing method