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Title:
KOSEIBUTSUSHITSU SFF837M1 BUTSUSHITSUNO 9*3**4* TORIASHIRUJUDOTAINO SEIZOHO
Document Type and Number:
Japanese Patent JPS5126887
Kind Code:
A
Abstract:
As new compounds are provided 9,3'',4''-trialkanoyl SF-837 M1 substances which have therapeutically useful antibacterial activity and do not show any objectionable long-lasting bitter taste upon its oral administration. These 9,3'',4''-trialkanoyl SF-837 M1 substances may be prepared from SF-837 substance, 9,2',3''-tri-acetyl SF-837 M1 substance, 9,2'-di-acetyl SF-837 substance, 9-propionyl SF-837 substance or 9,2'-dipropionyl SF-837 substance by acylating the latter with an alkanoic acid anhydride at 50 DEG -120 DEG C to produce the corresponding 9,2',3'',4''-tetra-alkanoyl SF-837 M1 substance and occasionally the 9,18,2',3'',4''-penta-alkanoyl SF-837 M1 substance, with involving the shift of the 4''-alkanoyl group to the 3''-hydroxyl group. Partial and selective hydrolysis of the 9,2',3'',4''-tetra-alkanoyl SF-837 M1substance and/or the 9,18,2',3'',4''-penta-alkanoyl SF-837 M1 substance so produced gives the desired 9,3'',4''-tri-alkanoyl SF-837 M1 substance.

Inventors:
OMOTO SHOJI
IWAMATSU KATSUYOSHI
INOE SHIGEHARU
NIITA TARO
KAWASAKI TOYOAKI
Application Number:
JP9748574A
Publication Date:
March 05, 1976
Filing Date:
August 27, 1974
Export Citation:
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Assignee:
MEIJI SEIKA CO
International Classes:
A61K31/70; A61K31/7042; A61K31/7048; A61P31/04; C07H17/08; (IPC1-7): A61K31/71; C07H17/08
Domestic Patent References:
JPS4836218A1973-05-28