To provide a new efficient synthesis method for industrially producing an L-type nucleic acid derivative as a medicine.
A method by which the L-type nucleic acid derivative can industrially be produced from L-arabinose, one of few industrially easily available L-type sugars, as a raw material in a short process is provided. Further, a synthetic intermediate useful for producing various L-type nucleic acid derivatives is provided. A new method for producing a new useful synthetic intermediate, 2,2'-anhydro-1-(β-L-arabinofuranosyl)thymine, is found. Further, a new method for producing L-thymine from the 2,2'-anhydro-1-(β-L- arabinofuranosyl)thymine is found. A new method for producing a useful synthetic intermediate, an L-2'-deoxyribose derivative, through the L-2,2'-anhydro-5,6- dihydrocyclouridine derivative is also found. Thereby, the synthesis of various L-type nucleic acid derivatives is possible, while the synthesis is difficult by conventional methods.
TOGASHI KAZUHIKO
SUZUKI TSUNESHI
