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Title:
L-TYPE NUCLEIC ACID DERIVATIVE AND METHOD FOR SYNTHESIZING THE SAME
Document Type and Number:
Japanese Patent JP3942414
Kind Code:
B2
Abstract:

PROBLEM TO BE SOLVED: To provide a new efficient synthesis method for industrially producing an L-type nucleic acid derivative as a medicine.
SOLUTION: A method by which the L-type nucleic acid derivative can industrially be produced from L-arabinose, one of few industrially easily available L-type sugars, as a raw material in a short process is provided. Further, a synthetic intermediate useful for producing various L-type nucleic acid derivatives is provided. A new method for producing a new useful synthetic intermediate, 2,2'-anhydro-1-(β-L-arabinofuranosyl)thymine, is found. Further, a new method for producing L-thymine from the 2,2'-anhydro-1-(β-L- arabinofuranosyl)thymine is found. A new method for producing a useful synthetic intermediate, an L-2'-deoxyribose derivative, through the L-2,2'-anhydro-5,6- dihydrocyclouridine derivative is also found. Thereby, the synthesis of various L-type nucleic acid derivatives is possible, while the synthesis is difficult by conventional methods.


Inventors:
飯塚 肇
富樫 和彦
鈴木 常司
Application Number:
JP2001000365022
Publication Date:
July 11, 2007
Filing Date:
November 29, 2001
Export Citation:
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Assignee:
三井化学株式会社
International Classes:
C07H3/08; C07H19/073; A61K31/7028; C07D498/04; C07D498/14; C07H9/06; C07H19/06; (IPC1-7): C07H3/08; C07H9/06; C07H19/06; C07H19/073; //A61K31/7028
Foreign References: