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Title:
LEUKOTRIENE ANTAGONISTIC AGENT CONTAINING 2,4-DIAMINO-1,3,5-TRIAZINE DERIVATIVE AS ACTIVE INGREDIENT
Document Type and Number:
Japanese Patent JPH04300832
Kind Code:
A
Abstract:

PURPOSE: To obtain a leukotriene antagonistic agent, containing a partially new 2,4-diamino-1,3,5-triazine derivative as an active ingredient and useful as a therapeutic and preventive agent for allergic, inflammatory, cardiovascular diseases, etc.

CONSTITUTION: A leukotriene antagonistic agent containing a partially new compound expressed by formula I (X and Y are H or acyl; R is substituted or unsubstituted phenyl, phthalidylmethyl or AR1; A is CH2CH2 or CH=CH; R1 is substituted or unsubstituted phenyl, naphthyl or pyridyl) or its pharmaceutically permissible salt, e.g. 2,4-diamino-(E)-6-[2-(3-pyridine) ethenyl]-3,5-triazine expressed by formula II as an active ingredient is obtained. The aforementioned compound can orally or parenterally be administered. In the case of the oral administration, the above-mentioned compound is normally preferably administered in a dose of 0.2-25mg/kg body weight expressed in terms of the aforementioned compound for an adult per day in several divided portions.


Inventors:
HASEGAWA YOSHIHIRO
OKUI YUKA
YANAGISAWA TOSHIHIKO
HOSAKA KUNIO
Application Number:
JP6682291A
Publication Date:
October 23, 1992
Filing Date:
March 29, 1991
Export Citation:
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Assignee:
TSUMURA & CO
International Classes:
A61K31/53; A61P9/00; A61P29/00; A61P37/08; C07D251/18; C07D401/06; C07D401/12; C07D401/14; C07D407/06; C12N9/99; (IPC1-7): A61K31/53; C07D251/18; C07D401/06; C07D401/12; C07D401/14; C07D407/06; C12N9/99