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Patent Searching and Data


Title:
LYSOGANGLIOSIDE DERIVATIVER
Document Type and Number:
Japanese Patent JPH02200697
Kind Code:
A
Abstract:

NEW MATERIAL: The N-acyl-lysogangliosdides derived from 2-24C aliphatic acid with its acyl group substituted by Cl, Br, F, OH, SH, COOH, sulfonic acid, nitrile, amino group or their derivatives, etc., as well as their derivatives obtained by esterification (amidification), internal esterification or peracylation of sialic acid carboxyl groups and salts.

EXAMPLE: N-dichloroacetyl lysoganglioside GM1.

USE: A therapeutic agent for metabolic encephalopathyl, injuries, neurodegenertion, mental disorders, etc.

PROCESS: Lysoganglioside derivatives are obtained, e.g. by acylating lysoganglioside, de-N-acetyl lysoganglioside, etc., with 2-24C aliphatic acid substituted by a polar group, after the functional group of the compound to be acrylated is tentatively protected. The functional carboxy group of the reaction product is esterified (amidified), internally esterified or peracylated upon occasions.


Inventors:
FURANSESUKO DERA BUATSURE
AURERIO ROMEO
Application Number:
JP1989000314135
Publication Date:
August 08, 1990
Filing Date:
December 02, 1989
Export Citation:
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Assignee:
FIDIA SPA
International Classes:
C07H1/00; A61K31/70; A61K31/7028; A61P25/00; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/28; C07H15/10; (IPC1-7): A61K31/70; C07H1/00; C07H15/12