Title:
抗炎症活性を有するマクロライド
Document Type and Number:
Japanese Patent JP5036558
Kind Code:
B2
Abstract:
The present invention relates to novel semi-synthetic macrolides having anti-inflammatory activity. More particularly, the invention relates to 14- and 15-membered macrolides substituted at the 4″ position, to their pharmaceutically acceptable derivatives, to processes and intermediates for their preparation, to pharmaceutical compositions containing them and to their activity and use in the treatment of inflammatory diseases and conditions in humans and animals, especially those diseases associated with excessive secretion of TNF-α, IL-1, IL-8, IL-2 or IL-5; and/or inhibitor of excessive lymphocyte proliferation; and/or excessive granulocyte degranulation.
Inventors:
Ognien Crick
Martina Bosnal
Nikola Malyanovic
Dubravko Yerick
Suleiman Ali Hosick
Wagna Vera
Zorika Marsic-Istuk
Vesna Erakovic
Belislav Bosniak
Bosca Fullvatic
Maria Tomaskovic
Vesna Munich
Vanessa Ivetic
Antun Futineck
Golan Cragol
Maria Leriak
Martina Bosnal
Nikola Malyanovic
Dubravko Yerick
Suleiman Ali Hosick
Wagna Vera
Zorika Marsic-Istuk
Vesna Erakovic
Belislav Bosniak
Bosca Fullvatic
Maria Tomaskovic
Vesna Munich
Vanessa Ivetic
Antun Futineck
Golan Cragol
Maria Leriak
Application Number:
JP2007550879A
Publication Date:
September 26, 2012
Filing Date:
January 13, 2006
Export Citation:
Assignee:
GLAXO GROUP LIMITED
International Classes:
C07H17/00; A61K31/7048; A61K31/7052; A61P1/04; A61P7/00; A61P7/10; A61P11/00; A61P11/02; A61P11/06; A61P17/06; A61P17/10; A61P19/02; A61P27/02; A61P29/00; A61P37/00; A61P43/00; C07H17/08
Domestic Patent References:
| JP59231051A | ||||
| JP2005535654A |
Foreign References:
| EP0895999A1 |
Attorney, Agent or Firm:
Aoyama Aoi
Takuji Yamada
Michiko Matsutani
Nishino Mitsuru
Mizuhara Masahiro
Takuji Yamada
Michiko Matsutani
Nishino Mitsuru
Mizuhara Masahiro