α4 MEDIATED CELL ADHESION INHIBITOR

Japanese Patent JP2005002116

A

To provide an α4 (including α4β7) mediated cell adhesion inhibitor effective for treating asthma, diabetes, and pathologic conditions associated with leukocyte invasion in the gastrointestinal tract and other epithelial tissue.

A compound expressed by formula (I) (ring A is an aromatic or heterocyclic ring; Q is a bond, carbonyl, a lower alkylene or the like; Z is O or S; W is O, S, -CH=CH- or -N=CH-; R1, R2 and R3 are each H, a halogen, hydroxy, a lower alkyl, a lower alkoxy, amino or the like; R4 is tetrazolyl, carboxy, amide or ester; R5 is H, nitro, amino, hydroxy or the like; R6 is phenyl, pyridyl or the like; and n is 0, 1 or 2) or its pharmacologically acceptable salt is provided.

YLLA SAAKAA
KURISUJAN S GUDOMANDOSON
RICHARD MARTIN

JP2004202046A

January 06, 2005

July 08, 2004

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TANABE SEIYAKU CO

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Aoyama Aoi
Kyousei Tamura

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